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CHEMOKINE CXCL4
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DeCS
Descriptor
English
:
Platelet Factor 4
Descriptor
Spanish
:
factor plaquetario 4
Descriptor
Portuguese
:
Fator Plaquetário 4
Synonyms
English
:
Antiheparin Factor
CXCL4 Chemokine
CXCL4, Chemokine
Chemokine CXCL4
Chemokine, CXCL4
Heparin Neutralizing Protein
PF4 (Platelet Factor 4)
gamma Thromboglobulin
gamma-Thromboglobulin
Tree Number:
D12.644.276.374.200.120.900
D12.776.124.125.720
D12.776.467.374.200.120.900
D23.119.940
D23.125.300.120.900
D23.469.200.120.900
D23.529.374.200.120.900
Definition
English
:
A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution.
Platelet factor 4
has a high affinity for
HEPARIN
and is often found complexed with
GLYCOPROTEINS
such as
PROTEIN C.
Pharmacological Action:
Coagulants
History Note
English
:
84(76); was see under BLOOD COAGULATION FACTORS 1976-83
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22259
Unique Identifier:
D010978
Occurrence in VHL
:
Similar:
DeCS